Journal
JOURNAL OF PROTEOME RESEARCH
Volume 13, Issue 1, Pages 260-267Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr4002977
Keywords
protein post-translational modification; PTM code; mouse brain development
Categories
Funding
- Lundbeck Foundation project grant in biomedicine
- Amazon Web Services AWS in Education Research Grant
- Danish Council for Independent Research, Natural Sciences
- Lundbeck Foundation Junior Group Leader Fellowship
- Lundbeck Foundation
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Protein post-translational modification (PTM) is a powerful way to modify the behavior of cellular proteins and thereby cellular behavior. Multiple recent studies of evolutionary trends have shown that certain pairs of protein post-translational modifications tend to occur closer to each other than expected at random. This type of observation may form the basis of a proposed PTM code, whereby protein function is controlled by complex patterns of multiple PTMs. This code could provide an additional, powerful level of regulatory control for protein function and is a plausible explanation for observations of increasingly frequent and diverse protein modification in cell biology. In this study, we use mass spectrometry and proteomic strategies to present biological data showing spatiotemporal PTM co-localization across multiple PTM categories, which display changes over development of the brain. This may be an indication of the existence of a PTM-based functional coding mechanism, which would significantly expand our view of the ways in which cells use protein PTMs in complex signaling networks.
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