Journal
JOURNAL OF PROTEOME RESEARCH
Volume 9, Issue 2, Pages 700-707Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr900256v
Keywords
Proteomics; Mass Spectrometry; Peptide Identification; Bioinformatics
Categories
Funding
- NIH [T32HG000046]
Ask authors/readers for more resources
Multi-stage search strategies have become widely accepted for peptide identification and are implemented in a number of available software packages. We describe limitations of these strategies for validation and decoy-based statistical analyses and demonstrate these limitations using a set of control sample spectra. We propose a solution that corrects the statistical deficiencies and describe its implementation using the open-source software XITandem.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available