Journal
JOURNAL OF PROTEOME RESEARCH
Volume 9, Issue 1, Pages 164-173Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr900273u
Keywords
Autoantibodies; protein array; bladder cancer; clusterin; dynamin
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Funding
- Spanish Ministry of Education and Science [SAF2006-08519]
- Spanish Ministry of Health
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Aiming at identifying biomarkers for bladder cancer, the serum proteome was explored in a pilot study through a profiling approach using protein arrays. Supervised analyses identified a panel 171 immunogenic proteins differentially expressed between patients with bladder cancer (n = 12) and controls without the disease (n = 10). The microanatomical expression patterns of novel immunogenic proteins, especially dynamin and clusterin, were found significantly associated with histopathologic variables and overall survival, as confirmed by immunohistochemistry using an independent series of bladder tumors contained in tissue microarrays (n = 289). Thus, the protein arrays approach has identified a panel of immunogenic candidates that may potentially play a role as diagnostic biomarkers, especially for muscle invasive disease. Moreover, the protein expression patterns of dynamin and clusterin in bladder tumors were shown to adjunct for histopathologic staging and clinical outcome prognosis.
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