Journal
JOURNAL OF PROTEOME RESEARCH
Volume 8, Issue 5, Pages 2140-2143Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr8009879
Keywords
quantitative proteomics; isotope labeling; clinical proteomics; (18)O-labeling; absolute quantitation; tissue proteomics; plasma proteome; biofilms; mitochondria; plasma membrane; formalin-fixed paraffin; laser capture micro-dissection; affinity fractionation; protein cross-linking; glycoproteins
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Enzyme-catalyzed (18)O(2)-labeling offers a universal strategy for uniform labeling of all peptides from any kind of proteins, including post-translationally modified proteins. It is applicable to clinical samples with unrivaled sensitivity. This review discusses strengths and limitations, and advocates the separation of proteolysis from the labeling step. Continued advances in software will facilitate widespread use of enzyme-catalyzed (18)O(2)-labeling to determine changes in protein abundances.
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