Journal
JOURNAL OF PROTEOME RESEARCH
Volume 8, Issue 4, Pages 2032-2044Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr801024g
Keywords
Endometrium; 2D PAGE; two-dimensional differential in-gel electrophoresis (2D DIGE); proteome; proliferative and secretory phases of the menstrual cycle; mass spectrometry; Rho-GDI alpha; CLIC1; PGRMC1
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Funding
- NHMRC of Australia [494802, 388901, 494803]
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This study aimed to identify proteins differentially expressed in the human endometrium between the proliferative and secretory phases of normal menstrual cycles by 2D differential in-gel electrophoresis (DIGE). A total of 196 out of 1017 spots were differentially expressed (p < 0.05). Mass spectrometry identified 76 proteins representing 41 different gene products. Immunohistochemistry confirmed the observed changes in 3 representative proteins (Rho-GDI alpha, CLIC1, PGRMC1). Biological pathway analysis identified the Jnk and EGF signaling pathways as key regulators of protein expression in the midsecretory phase of endometrial proteome.
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