Journal
JOURNAL OF PROTEOME RESEARCH
Volume 8, Issue 7, Pages 3666-3674Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr800937k
Keywords
MHC class I; MHC class II; phosphopeptide; renal cell carcinoma; titanium dioxide; phosphosite; Brf1; Frizzled 6; CXCR4; CD20
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Funding
- Deutsche Forschungsgemeinschaft [SFB 685]
- Bundesministerium fur Bildung und Forschung (BMBF, QuantPro)
- Stiftung der deutschen Wirtschaft - Studienstiftung Klaus Murmann
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MHC molecules present protein-derived peptides to T lymphocytes. By developing TiO2-based microcentrifugation columns, we identified the first phosphorylated MHC class I ligands from tumor tissue (renal cell carcinoma) and, by comparison to healthy renal tissue, found one Brf1-derived ligand as potentially tumor-associated. We further discovered the first natural phosphorylated MHC class 11 ligands. They revealed several novel phosphorylation sites of significant transmembrane receptors, such as Frizzled 6, CXCR4 and CD20.
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