Journal
JOURNAL OF PROTEOME RESEARCH
Volume 8, Issue 2, Pages 1071-1076Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr800945b
Keywords
2D-PAGE; orbitrap mass spectrometry; glycosylation; fragment; sport
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Funding
- World Anti-Doping Agency
- Federal Ministry of Education and Research of Germany
- Federal Ministry of the Interior of the Federal Republic of Germany
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The heterogeneity of human endogenous growth hormone (GH) is used in doping control analysis to distinguish it from the homogeneous recombinant analogue in plasma samples. Pituitary GH variants were characterized by gel electrophoresis and mass spectrometry. Besides 22 and 20 We isoforms, fragments of 9 and 12 kDa were identified and a glycosylated 23 kDa GH variant was elucidated to bear a HexHexNac*2 NeuAc modification presumably located at Thr 60.
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