Journal
JOURNAL OF PROTEOME RESEARCH
Volume 8, Issue 3, Pages 1271-1284Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr800601x
Keywords
neuropeptide; Drosophila; mass spectrometry; MALDI-TOF; biogenic amine; dopamine; serotonin
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Funding
- National Institute of Mental Health National Research Service Award
- National Institute of Diabetes and Digestive and Kidney Diseases [DK071801]
- National Institute of General Medical Sciences [GM074675, GM067645]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R56DK071801, R01DK071801] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067645, R01GM074675] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [F32MH072127] Funding Source: NIH RePORTER
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A combined approach using mass spectrometry, a novel neuron affinity capture technique, and Drosophila melanogaster genetic manipulation has been developed to characterize the expression and localization of neuropeptides in the adult D. melanogaster brain. In extract from the whole adult brain, 42 neuropeptides from 18 peptide families were sequenced. Neuropeptide profiling also was performed on targeted populations of cells which were enriched with immunoaffinity purification using a genetically expressed marker.
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