Journal
PHYSIOLOGY
Volume 30, Issue 3, Pages 241-250Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00025.2014
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Funding
- Canadian Institutes of Health Research
- Crohn's and Colitis Canada
- Vertex Pharmaceuticals
- Natural Sciences and Engineering Research Council of Canada
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The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier. Since then, several studies have emphasized the importance of NLRs in maintaining gut homeostasis and intestinal infections, and in shaping the microbiota. In this review, we will highlight the function of NLRs in intestinal inflammation.
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