Journal
PHYSIOLOGY
Volume 30, Issue 5, Pages 340-348Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00022.2015
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Funding
- National Heart, Lung, and Blood Institute [PO1-HL-90554, UH2-HL-123610]
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The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.
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