Journal
JOURNAL OF PROCESS CONTROL
Volume 18, Issue 2, Pages 149-162Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jprocont.2007.07.008
Keywords
diabetes; control; glucose
Funding
- NIDDK NIH HHS [R21 DK069833-02, R21 DK069833, R21 DK069833-01] Funding Source: Medline
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As the artificial pancreas becomes closer to reality, automated insulin delivery based on real-time glucose measurements becomes feasible for people with diabetes. This paper is concerned with the development of novel feedforward-feedback control strategies for realtime glucose control and type I diabetes. Improved post-meal responses can be achieved by a pre-prandial snack or bolus, or by reducing the glucose setpoint prior to the meal. Several feedforward-feed back control strategies provide attractive alternatives to the standard meal insulin bolus and are evaluated in simulations using a physiological model. (c) 2007 Elsevier Ltd. All rights reserved.
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