Journal
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Volume 16, Issue 1, Pages 85-92Publisher
WORLD SCI PUBL CO INC
DOI: 10.1142/S108842461100435X
Keywords
amidinophenylporphyrin; singlet oxygen; DNA cleavage; binding mode
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Funding
- National Natural Science Foundation of China [20902071, 20672082]
- Hong Kong Research Grants Council [HKBU 202407]
- Key Laboratory for Green Chemical Process of Ministry of Education in China [RGCT201003]
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5,10,15,20-tetrakis(4-amidinophenyl) porphyrin (Por 1), its Zn complex (Por 2) and its conjugate with a tetraphenylporphyrin to form a bisporphyrin (Por 3) were prepared. The monomeric Por 1 and Por 2 showed both intercalative and external binding with DNA whereas only external DNA binding was seen in the bisporphyrin, Por 3 by circular dichroism and UV-vis. The DNA photocleavage activities of these porphyrins followed the order: Por 1 similar to Por 2 > Por 3, which did not correlate with their measured O-1(2) production rates. It suggests 4-amidinophenylporphyrins are promising new photodynamic therapeutic agents.
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