Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 52, Issue 21, Pages 3118-3122Publisher
WILEY
DOI: 10.1002/pola.27364
Keywords
cationic polymerization; copolymerization; glass transition; living polymerization; lower critical solution temperature; poly(2-oxazoline)s; ring-opening polymerization
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Funding
- FWO via a Pegasus Marie Curie Fellowship
- Special Research Fund of Ghent University (BOF-UGent)
- Research Foundation - Flanders (FWO)
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Poly(2-propyl-oxazoline)s can be prepared by living cationic ring-opening polymerization of 2-oxazolines and represent an emerging class of biocompatible polymers exhibiting a lower critical solution temperature in aqueous solution close to body temperature. However, their usability is limited by the irreversibility of the transition due to isothermal crystallization in case of poly(2-isopropyl-2-oxazoline) and the rather low glass transition temperatures (T-g<45 degrees C) of poly(2-n-propyl-2-oxazoline)-based polymers. The copolymerization of 2-cyclopropyl-2-oxazoline and 2-ethyl-2-oxazoline presented herein yields gradient copolymers whose cloud point temperatures can be accurately tuned over a broad temperature range by simple variation of the composition. Surprisingly, all copolymers reveal lower T(g)s than the corresponding homopolymers ascribed to suppression of interchain interactions. However, it is noteworthy that the copolymers still have T(g)s>45 degrees C, enabling convenient storage in the fridge for future biomedical formulations. (c) 2014 Wiley Periodicals, Inc.
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