Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 52, Issue 14, Pages 1962-1969Publisher
WILEY-BLACKWELL
DOI: 10.1002/pola.27203
Keywords
nanoparticles; oligomers; step-growth polymerization; stimuli-sensitive polymers
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Funding
- National Natural Science Foundation of China [21174005, 21274004]
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The azomethine-based oligomers bearing boronate groups and imine moieties in the main chain were synthesized from a dialdehyde monomer and an aromatic (oligomer 4) diamine or an aliphatic diamine (oligomer 5). Based on the oligomers, the nanoparticles with hydrogen peroxide (H2O2) and pH dual-responsive properties were constructed and encapsulated nile red inside. The nanoparticles disassembled either by the trigger of H2O2 or by the attack of H+, thus leading to the release of loaded species. Compared to oligomer 4, oligomer 5 showed a faster degradation rate in the presence of H2O2, especially in a weak acidic environment. No significant cytotoxicity was observed as HeLa cells incubated in the nanoparticles with the concentration up to 200 g/mL evidenced by cytotoxicity assay in vitro. Such a system capable of dual response of H2O2 and H+ may have potential application as a carrier for drug delivery. (c) 2014 Wiley Periodicals, Inc.
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