Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 52, Issue 14, Pages 2057-2067Publisher
WILEY-BLACKWELL
DOI: 10.1002/pola.27216
Keywords
atom transfer radical polymerization (ATRP); block copolymers; self-assembly; stimuli-sensitive polymers
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Funding
- NSERC Discovery Grant
- Canada Research Chair (CRC) Award
- NSERC Undergraduate Summer Research Award (USRA)
- FQRNT
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New poly(ethylene oxide)-based block copolymers (ssBCs) with a random copolymer block consisting of a reduction-responsive disulfide-labeled methacrylate (HMssEt) and a thermoresponsive di(ethylene glycol)-containing methacrylate (MEO2MA) units were synthesized. The ratio of HMssEt/MEO2MA units in the random P(MEO2MA-co-HMssEt) copolymer block enables the characteristics of well-defined ssBCs to be amphiphilic or thermoresponsive and double hydrophilic. Their amphiphilicity or temperature-induced self-assembly results in nanoaggregates with hydrophobic cores having different densities of pendant disulfide linkages. The effect of disulfide crosslinking density on morphological variation of disulfide-crosslinked nanogels is investigated. In response to reductive reactions, the partial cleavage of pendant disulfide linkages in the hydrophobic cores converts the physically associated aggregates to disulfide-crosslinked nanogels. The occurrence of in-situ disulfide crosslinks provides colloidal stability upon dilution. (c) 2014 Wiley Periodicals, Inc.
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