Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 51, Issue 3, Pages 732-738Publisher
WILEY
DOI: 10.1002/pola.26437
Keywords
chiral polymer; circular dichroism; cloud point; hydrophilic; LCST; polyoxazoline
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [JO287/4-3]
- United States National Institutes of Health (NIH) of the National Cancer Institute (NCI) [CA151806]
- Deutsche Forschungsgemeinschaft (DFG) through the Center of Excellence for Regenerative Therapies Dresden (CRTD)
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We describe the synthesis and characterization of the first water-soluble and chiral poly(2,4-disubstituted-2-oxazoline)s. While poly(2,4-dimethyl-2-oxazoline) s are water soluble up to 100 degrees C, aqueous solutions of poly(2-ethyl-4-methly-2-oxazoline) exhibit a lower critical solution temperature. This is discussed in context with its constitutional isomers poly(2-oxazoline) s and poly(2-oxazine)s. Circular dichroism spectroscopy revealed strong Cotton effects, which are also responsive to temperature in aqueous solution. It is therefore hypothesized that structures, comparable to polyproline helices, are formed in aqueous solution. In contrast to polyproline, poly(2,4-disubstituted-2oxazoline) s are highly water soluble and therefore represent very interesting pseudo-polypeptides that may be useful to develop responsive biomimetic biomaterials. (C) 2012 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 732-738
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