Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 48, Issue 16, Pages 3604-3612Publisher
WILEY
DOI: 10.1002/pola.24141
Keywords
drug delivery systems; hydrogels; living radical polymerization (LRP); reducible degradation; stimuli-sensitive polymers; stimulus-response
Categories
Funding
- NSFC [20934005]
- Ministry of Science and Technology of China [2007CB936401]
- HKSAR [403706]
- China Education Ministry
Ask authors/readers for more resources
Reducibly degradable hydrogels of poly(N-isopropylacrylamide) (PNIPAM) and poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and click chemistry. The alkyne-pending copolymer of PNIPAM or PDMAEMA was obtained through RAFT copolymerization of propargyl acrylate with NIPAM or DMAEMA. Bis-2-azidyl-isobutyrylamide of cystamine (AIBCy) was used as the crosslinking reagent to prepare reducibly degradable hydrogels by click chemistry. The hydrogels exhibited temperature or pH stimulus-responsive behavior in water, with rapid response, high swelling ratio, and reproducible swelling/shrinkage cycles. The loading and release of ceftriaxone sodium proved the feasibility of the hydrogels as the stimulus-responsive drug delivery system. Furthermore, the presence of disulfide linkage in AIBCy favored the degradation of hydrogels in the reductive environment. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 3604-3612, 2010
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available