Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 47, Issue 5, Pages 1412-1421Publisher
WILEY
DOI: 10.1002/pola.23250
Keywords
glycopolymer; molecular recognition; nanoparticles; reversible addition fragmentation chain transfer (RAFT)
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Funding
- Young Scientists (B) [20750088]
- Grants-in-Aid for Scientific Research [20750088] Funding Source: KAKEN
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Glycopolymer-substituted gold nanoparticles were prepared via living radical polymerization with a reversible addition-fragmentation chain transfer (RAFT) reagent. Polyacrylamide derivatives with alpha-mannose (alpha-Man) and N-acetyl-beta-glucosamine (beta-GlcNAc) were synthesized and hydrogenated to obtain thiol-terminated polymer. The thiol-terminated glycopolymers were mixed with gold nanoparticles to yield the polymer substituted gold nanoparticles with various diameters, which aggregated on addition of saccharide-recognition proteins (lectins). The aggregation properties were analyzed using transmission electron microscopy and UV spectra. Molecular recognition was studied with E. coli, which induced aggregation of the nanoparticles at the cell periphery. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 1412-1421, 2009
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