Heterograft Copolymers via Double Click Reactions Using One-Pot Technique

The double click reactions (Cu catalyzed Huisgen and Diels-Alder reactions) were used as a new strategy for the preparation of well-defined heterograft copolymers in one-pot technique. The synthetic strategy to the various stages of this work is outlined: (i) preparing random copolymers of styrene (St) and p-chloromethylstyrene (CMS) (which is a functionalizable monomer) via nitroxide mediated radical polymerization (NMP); (ii) attachment of anthracene functionality to the preformed copolymer by the o-etherification procedure and then conversion of the remaining -CH2Cl into azide functionality; (iii) by using double click reactions in one-pot technique, maleimide end-functionalized poly(methyl methacrylate) (PMMA-MI) via atom transfer radical polymerization (ATRP) of MMA and alkyne end-functionalized poly (ethylene glycol) (PEG-alkyne) were introduced onto the copolymer bearing pendant anthryl and azide moieties. (c) 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46:6969-6977, 2008