Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 46, Issue 16, Pages 5638-5651Publisher
WILEY
DOI: 10.1002/pola.22885
Keywords
ATRP; double hydrophilic; graft copolymers; synthesis
Categories
Funding
- Shanghai Nano-Technology Program [0652nm031]
- Shanghai Rising Star Program [07QA14066]
- Chinese Academy of Sciences
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A series of well-defined double hydrophilic graft copolymers, consisting of poly(N-isopropylacrylamide)-b-poly(ethyl acrylate) (PNIPAM-b-PEA) backbone and poly(2-(diethylamino)ethyl methacrylate) (PDEA) side chains, were synthesized by successive atom transfer radical polymerization (ATRP). The backbone was firstly prepared by sequential ATRP of N-isopropylacrylamide and 2-hydroxyethyl acrylate at 25 degrees C using CuCl/tris(2-(dimethylamino)ethyl)amine as catalytic system. The obtained diblock copolymer was transformed into macroinitiator by reacting with 2-chloropropionyl chloride. Next, grafting-from strategy was employed for the synthesis of poly(N-isopropylacrylamide)-b-[poly(ethyl acrylate)-g-poly(2-(diethylamino)ethyl methacrylate)] (PNIPAM-b-(PEA-g-PDEA)) double hydrophilic graft copolymer. ATRP of 2-(diethylamino)ethyl methacrylate was initiated by the macroinitiator at 40 degrees C using CuCl/hexamethyldiethylenetriamine as catalytic system. The molecular weight distributions of double hydrophilic graft copolymers kept narrow. Thermo- and pH-responsive micellization behaviors were investigated by fluorescence spectroscopy, H-1 NMR, dynamic light scattering, and transmission electron microscopy. Unimolecular micelles with PNIPAM-core formed in acidic environment (pH = 2) with elevated temperature (>= 32 degrees C); whereas, the aggregates turned into vesicles in basic surroundings (pH >= 7.2) at room temperature. (C) 2008 Wiley Periodicals, Inc.
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