Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 46, Issue 23, Pages 7713-7724Publisher
WILEY
DOI: 10.1002/pola.23075
Keywords
atom transfer radical polymerization (ATRP); biocompatibility; biomaterials; biomimetic; blood; coagulation; films; heparin; in vitro; polymer brushes; sugars; sulfonated; surfaces
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Funding
- NIH [EB001473, EB00894]
- Eccles Foundation
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A new polymer brush chemistry containing sulfonated carbohydrate repeat units has been synthesized from silicon substrates using ATRP methods and characterized both in bulk and using surface analysis. The polymer brush was designed to act as a mimic for the naturally occurring sulfonated glycosaminoglycan, heparin, commonly used for modifying blood-contacting surfaces both in vitro and in vivo. Surface analysis showed conversion of brush saccharide precursor chemistry to the desired sulfonated polymer product. The sulfonated polymer brush surface was further analyzed using three conventional in vitro tests for blood compatibility-plasma recalcification times, complement activation, and thrombin generation. The sulfonated polymer brush films on silicon oxide wafers exhibited better assay performance in these blood component assays than the unsulfonated sugar functionalized polymer brush in all tests performed. (C) 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7713-7724, 2008
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