UV photopolymerized hydrogels with β-cyclodextrin moieties

Hydrophilic hydrogels based on poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) block copolymers have potential applications in drug delivery, tissue engineering and other biomedical devices due to their excellent biocompatibility and environmental sensitivity. However, they also exhibit some shortcomings in terms of swelling and mechanical properties as well as affinity for water-insoluble or hydrophobic drug molecules. To address these limitations, new polymeric hydrogels with beta-cyclodextrin moieties were prepared by UV photo-polymerization of maleic anhydride-substituted beta-CD (MAH-CD) and the block copolymer macromer from Pluronic F68 and poly(beta-caprolactone). Their swelling and dynamic rheological properties were investigated with respect to the effects of feed compositions. It was found that the swelling ratio, storage modulus and loss modulus of the resulting hydrogel increased with the increase of MAH-CD amount. Incorporation of MAH-CD resulted in strong viscoelastic system with dominating elastic behavior.