Journal
JOURNAL OF PHYSIOLOGY-PARIS
Volume 104, Issue 1-2, Pages 40-50Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jphysparis.2009.11.009
Keywords
Biophysical model; Cortical column; Optical imaging; Mesoscopic scale; Voltage-sensitive dyes
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In this review, we present the voltage-sensitive dye imaging (VSDI) method. The possibility offered for in vivo (and in vitro) brain imaging is unprecedented in terms of spatial and temporal resolution. However, the unresolved multi-component origin of the optical signal encourages us to perform a detailed analysis of the method limitation and the existing models. We propose a biophysical model at a mesoscopic scale in order to understand and interpret this signal. (C) 2009 Elsevier Ltd. All rights reserved.
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