Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 596, Issue 21, Pages 5083-5098Publisher
WILEY
DOI: 10.1113/JP276338
Keywords
Non-human primate; Cardiac function; Aging
Categories
Funding
- NIA NIH HHS [U19 AG057758] Funding Source: Medline
- NIBIB NIH HHS [T32 EB000817] Funding Source: Medline
- NIH HHS [P51 OD011133] Funding Source: Medline
Ask authors/readers for more resources
Previous studies reported cardiac function declines with ageing. This study determined changes in biventricular cardiac function in a well-characterized baboon model. Cardiac magnetic resonance imaging measured key biventricular parameters in 47 baboons (22 female, age 4-23 years). ANCOVA assessed sex and age changes with P < 0.05 deemed significant. Stroke volume, cardiac output and other cardiac functional parameters were normalized to body surface area. There were similar, age-related rates of decrease in male (M) and female (F) normalized left ventricular (LV) myocardial mass index (M: -1.2 g m(-2) year(-1), F: -0.9 g m(-2) year(-1)). LV ejection fraction declined at -0.96% year(-1) (r = -0.43, P = 0.002) and right ventricular (RV) ejection fraction decreased at -1.2% year(-1) (r = -0.58, P < 0.001). Normalized LV stroke volume fell at -1.1 ml m(-2) year(-1) (r = -0.47, P = 0.001), normalized LV ejection rate at -3.8 ml s(-1) m(-2) year(-1) (r = -0.43, P < 0.005) and normalized LV filling rate at -4.1 ml s(-1) m(-2) year(-1) (r = -0.44, P < 0.005). Also, RV wall thickening fraction decreased with age (slope = -1% year(-1), P = 0.008). RV ejection rate decreased at -3.6 ml s(-1) m(-2) year(-1) (P = 0.002) and the normalized average RV filling rate dropped at -3.7 ml s(-1) m(-2) year(-1) (P < 0.0001). End-systolic RV sphericity index also dropped with age (r = -0.33, P = 0.02). Many observed changes parallel previously reported data in human and animal studies. These measured biventricular functional declines in hearts with ageing from the closest experimental primate species to man underscore the utility of the baboon model for investigating mechanisms related to heart ageing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available