Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 593, Issue 15, Pages 3261-3266Publisher
WILEY
DOI: 10.1113/jphysiol.2014.281147
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Funding
- Association Francaise contre les Myopathies (AFM)
- Fondation Daniel Ducoin
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Vivier de la Recherche de la Faculte de Medecine de Grenoble
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The calcium release complex is the major player in excitation-contraction coupling, both in cardiac and skeletal muscle. The core of the complex is the ryanodine receptor, and triadin is a regulating protein. Nevertheless, the precise function of triadin is only partially understood. Besides its function in the anchoring of calsequestrin at the triad/dyad, our recent results allow us to propose hypotheses on new triadin scaffolding functions, based on the studies performed using different models, from triadin knockout mice to human patients, and expression in non-muscle cells, taking into account the presence of multiple triadin isoforms.
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