Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 589, Issue 23, Pages 5663-5676Publisher
WILEY
DOI: 10.1113/jphysiol.2011.215384
Keywords
-
Categories
Funding
- National Institutes of Health, Bethesda, MD
- GlaxoSmithKline Pharmaceuticals, USA
- CEVYPET (EU)
- VEGA [1/0276/10]
Ask authors/readers for more resources
Non-technical summary Sodium channels are obligatory for the conduction of action potentials along axons. There are several different sodium channel subtypes expressed in vagal sensory neurons, and it is difficult to pharmacologically block these subtypes selectively. We used virally delivered shRNA to selectively block the production of one of the sodium channel subtypes expressed in vagal sensory neurons, namely NaV1.7, and found that by selectively inhibiting the expression of this channel the conduction of action potentials was blocked in the majority of vagal sensory neurons. This study also shows that NaV1.7 is required for the elicitation of classical vagal reflexes such as cough.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available