Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 587, Issue 1, Pages 33-40Publisher
WILEY
DOI: 10.1113/jphysiol.2008.164400
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Funding
- Fonds National de la Recherche Scientifique
- NARSAD
- Fondation Leon Fredericq
- NIDA DARPA
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Sleep disturbances are associated with hormonal imbalances and may result in metabolic disorders including obesity and diabetes. Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions. The hypocretin (Hcrt) system is a strong candidate for mediating both sleep and metabolic imbalances because Hcrt neurons are sensitive to metabolic hormones, including leptin and ghrelin, and modulate arousal and goal-orientated behaviours. This review discusses the role of Hcrt neurons as a sensors of energy balance and arousal and proposes new ways of probing local hypothalamic circuits regulating sleep and metabolism with unprecedented cellular specificity and temporal resolution.
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