Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 586, Issue 4, Pages 1195-1205Publisher
BLACKWELL PUBLISHING
DOI: 10.1113/jphysiol.2007.144113
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Funding
- NCRR NIH HHS [UL1 RR024150, RR-024150] Funding Source: Medline
- NHLBI NIH HHS [F32 HL078019, HL-78019, HL-46493, R01 HL046493] Funding Source: Medline
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We previously reported that hypoxia-mediated reductions in alpha-adrenoceptor sensitivity do not explain the augmented vasodilatation during hypoxic exercise, suggesting an enhanced vasodilator signal. We hypothesized that beta-adrenoceptor activation contributes to augmented hypoxic exercise vasodilatation. Fourteen subjects (age: 29 +/- 2 years) breathed hypoxic gas to titrate arterial O-2 saturation (pulse oximetry) to 80%, while remaining normocapnic via a rebreath system. Brachial artery and antecubital vein catheters were placed in the exercising arm. Under normoxic and hypoxic conditions, baseline and incremental forearm exercise (10% and 20% of maximum) was performed during control (saline), alpha-adrenoceptor inhibition (phentolamine), and combined alpha- and beta-adrenoceptor inhibition (phentolomine/propranolol). Forearm blood flow (FBF), heart rate, blood pressure, minute ventilation, and end-tidal CO2 were determined. Hypoxia increased heart rate (P < 0.05) and minute ventilation (P < 0.05) at rest and exercise under all drug infusions, whereas mean arterial pressure was unchanged. Arterial adrenaline (P < 0.05) and venous noradrenaline (P < 0.05) were higher with hypoxia during all drug infusions. The change (Delta) in FBF during 10% hypoxic exercise was greater with phentolamine (Delta 306 +/- 43 ml min(-1)) vs. saline (Delta 169 +/- 30 ml min(-1)) or combined phentolamine/propranolol (Delta 213 +/- 25 ml min(-1); P < 0.05 for both). During 20% hypoxic exercise, Delta FBF was greater with phentalomine (Delta 466 +/- 57 ml min(-1); P < 0.05) vs. saline (Delta 346 +/- 40 ml min(-1)) but was similar to combined phentolamine/propranolol (Delta 450 +/- 43 ml min(-1)). Thus, in the absence of overlying vasoconstriction, the contribution of beta-adrenergic mechanisms to the augmented hypoxic vasodilatation is dependent on exercise intensity.
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