Journal
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 69, Issue 3, Pages 371-381Publisher
SPRINGER
DOI: 10.1007/s13105-012-0219-2
Keywords
Apricot; Kidney; Apoptosis; Nutritional antioxidants; Rat
Categories
Funding
- Scientific Research Fund of Inonu University [2005/78]
- Apricot Research Foundation of Malatya Province
Ask authors/readers for more resources
This study was conducted to evaluate a possible protective role of apricot in apoptotic cell death induced by methotrexate (MTX) and renal damage by different histological and biochemical parameters. Twenty-eight rats were divided into four groups, control, apricot, methotrexate, and apricot + methotrexate. Methotrexate induced renal failure, as shown by significant serum creatinine and urea elevation. Additionally, the results indicated that methotrexate significantly induced lipid peroxidation and reduced antioxidant activities in rats. In contrast, apricot significantly prevented toxic effects of methotrexate via increased catalase, superoxide dismutase, and glutathione levels but decreased formation of malondialdehyde. Also, it was determined that exposure to methotrexate leads to significant histological damage in kidney tissue such as glomerulosclerosis and apoptosis. On the other hand, these effects can be eliminated with apricot diet. These data indicate that apricot may be useful in preventing undesirable effects of MTX such as nephrotoxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available