Journal
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 65, Issue 3, Pages 305-312Publisher
SPRINGER
DOI: 10.1007/BF03180583
Keywords
Alcohol; Mitochondria; Brain; Glutathione; Cholesterol; Rat; Apoptosis
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Funding
- Ministerio de Ciencia e Innovacion [SAF 200766801]
- Plan Nacional de Investigacion Cientifica
- Instituto de Salud Carlos III
- Universidad CEU-Cardenal Herrera
- FEPAD (Fundacion para el Estudio, Prevencion y Ayuda a la Drogadiccion)
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I. ALMANSA, A. FERNANDEZ, C. GARCIA-RUIZ, M. MURIACH, J.M. BARCIA, M. MIRANDA, J.C. FERNANDEZ-CHECA and F.J. ROMERO. Brain mitochondrial alterations after chronic alcobol consumption. J Physiol Bio-chem, 65 (3), 305-312, 2009. The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the Increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins.
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