Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 64, Issue 1, Pages 47-57Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12576-013-0289-0
Keywords
Monoterpene; Pain relief; TRPA1; Hydroxyl group
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology in Japan
Ask authors/readers for more resources
TRPA1, one of the transient receptor potential channels, has been reported to be involved in nociception and inflammatory pain, suggesting that this molecule could be a promising target for the development of analgesic agents. We screened several monoterpene analogs of camphor, which is known to inhibit human (h) TRPA1, to identify more effective naturally occurring TRPA1 antagonists. Borneol, 2-methylisoborneol, and fenchyl alcohol exhibited higher inhibitory effects on hTRPA1 activity than either camphor or 1,8-cineole. Our results revealed further that the S873, T874, and Y812 residues of hTRPA1 were involved in the inhibitory effects, suggesting that the hydroxyl group in the six-membered ring of the inhibitors may be interacting with these amino acids. Further research on these identified TRPA1 antagonists could lead to new pain therapeutics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available