Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 64, Issue 2, Pages 151-156Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12576-013-0297-0
Keywords
Oxaliplatin; Cold allodynia; Electroacupuncture; Endogenous opioid; Noradrenergic
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Funding
- Kyung Hee University [KHU-20120460]
- National Research Foundation of Korea (NRF)
- Korea government [MEST] [2012-0005755]
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This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into cold water (4 A degrees C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) was delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) EA at ST36 relieved cold allodynia more effectively than high-frequency EA at ST36 or low-frequency EA at non-acupoint. Naloxone (opioid antagonist, 2 mg/kg, i.p.) completely blocked such EA-induced anti-allodynia, whereas phentolamine (alpha-adrenergic antagonist, 2 mg/kg, i.p.) did not. Moreover, plasma beta-endorphin levels significantly increased right after the end of EA and subsequently decreased. These results indicate that low-frequency EA at ST36 in rats has a marked relieving effect on oxaliplatin-induced cold allodynia that is mediated by the endogenous opioid, but not noradrenergic, system.
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