Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 60, Issue 7, Pages 2703-2713Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/60/7/2703
Keywords
terahertz spectroscopy; dehydration; gelatin
Funding
- Research Grants Council of Hong Kong [415313]
- CUHK Direct Grant [4055001]
- Hong Kong Innovation and Technology Scheme [ITS/198/12]
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Sample dehydration has traditionally been a challenging problem in ex vivo terahertz biomedical experiments as water content changes significantly affect the terahertz properties and can diminish important contrast features. In this paper, we propose a novel method to prevent sample dehydration using gelatin embedding. By looking at terahertz image data and calculating the optical properties of the gelatin-embedded sample, we find that our method successfully preserves the sample for at least 35 h, both for imaging and spectroscopy. Our novel preservation method demonstrates for the first time the capability to simultaneously maintain sample structural integrity and prevent dehydration at room temperature. This is particularly relevant for terahertz studies of freshly excised tissues but could be beneficial for other imaging and spectroscopy techniques.
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