Journal
JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume 51, Issue 40, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6463/aad898
Keywords
AFM; nanoscale dynamics; time-lapse imaging; chromatin dynamics; protein-DNA interactions
Categories
Funding
- NIH [R01 GM096039, R01GM118006, R01 GM100156, R21 NS101504]
- NSF [MCB 1515346]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM096039, R01GM100156, R01GM118006] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS101504] Funding Source: NIH RePORTER
Ask authors/readers for more resources
High-speed atomic force microscopy (HS-AFM) is an advanced technique with numerous applications in biology, particularly in molecular biophysics. Developed as a time-lapse AFM technique for direct imaging fully hydrated biological molecules, HS-AFM is currently capable of visualizing the dynamics of biological molecules and their complexes at a video-data acquisition rate. Spatial resolution at the nanometer level is another important characteristic of HS-AFM. This review focuses on examples of primarily protein-DNA complexes to illustrate the high temporal and spatial resolution capabilities of HS-AFM that have resulted in novel models and/or the functional mechanisms of these biological systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
