Journal
JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume 45, Issue 7, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0022-3727/45/7/073001
Keywords
-
Categories
Funding
- European Community [212043]
Ask authors/readers for more resources
The advent of nanotechnology has introduced a variety of novel exciting possibilities into the medical and clinical field. Nanoparticles, ultra-small object sized between 100 and 1 nm, are promising diagnostic tools for various diseases among other devices, thanks to the possibility of their functionalization allowing the selective targeting of organs, tissues and cells and to facilitate their transport to primary target organs. However, brain targeting represents a still unresolved challenge due to the presence of the blood-brain barrier, a tightly packed layer of endothelial cells that prevents unwanted substances entering the central nervous system. We review a range of nanoparticles suitable for in vivo diagnostic imaging of neurodegenerative diseases and brain disorders, highlighting the possibility to potentially increase their efficiency and kinetics of brain-targeting. We also review a range of imaging techniques with an emphasis on most recently introduced molecular imaging modalities, their current status and future potential.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available