Journal
PHYSICAL REVIEW LETTERS
Volume 114, Issue 4, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.114.048101
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Funding
- National Science Foundation [DMR-0820341, DMS-0920930, EF-ATB-1137822, DMR-0847685, DMR-0820579, CNS-0821794]
- U.S. Department of Energy [DE-FG02-88ER25053]
- National Institutes of Health [R01 GM104976-03]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0847685] Funding Source: National Science Foundation
- Emerging Frontiers
- Direct For Biological Sciences [1137822] Funding Source: National Science Foundation
- U.S. Department of Energy (DOE) [DE-FG02-88ER25053] Funding Source: U.S. Department of Energy (DOE)
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Microtubules and motor proteins are building blocks of self-organized subcellular biological structures such as the mitotic spindle and the centrosomal microtubule array. These same ingredients can form new bioactive liquid-crystalline fluids that are intrinsically out of equilibrium and which display complex flows and defect dynamics. It is not yet well understood how microscopic activity, which involves polarity-dependent interactions between motor proteins and microtubules, yields such larger-scale dynamical structures. In our multiscale theory, Brownian dynamics simulations of polar microtubule ensembles driven by cross-linking motors allow us to study microscopic organization and stresses. Polarity sorting and cross-link relaxation emerge as two polar-specific sources of active destabilizing stress. On larger length scales, our continuum Doi-Onsager theory captures the hydrodynamic flows generated by polarity-dependent active stresses. The results connect local polar structure to flow structures and defect dynamics.
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