Journal
PHYSICAL REVIEW LETTERS
Volume 114, Issue 17, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.114.178102
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Funding
- IRSES project [FP7-PEOPLE-2010-IRSES 269139 DCP-PhysBio]
- RFBR [14-03-00825]
- Skolkovo Institute of Science and technology via SkolTech/MSU Joint Laboratory [081-R]
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The fractal globule state is a popular model for describing chromatin packing in eukaryotic nuclei. Here we provide a scaling theory and dissipative particle dynamics computer simulation for the thermal motion of monomers in the fractal globule state. Simulations starting from different entanglement-free initial states show good convergence which provides evidence supporting the existence of a unique metastable fractal globule state. We show monomer motion in this state to be subdiffusive described by [X-2 (t)] similar to t(aF) with alpha(F) close to 0.4. This result is in good agreement with existing experimental data on the chromatin dynamics, which makes an additional argument in support of the fractal globule model of chromatin packing.
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