Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 2, Issue 12, Pages 1387-1389Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jz2005495
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Funding
- Czech Science Foundation [203/08/0114]
- Ministry of Education [LC 512, MSM0021620857]
- Academy of Sciences (Praemium Academie)
- Grant Agency of Charles University [SVV261204]
- IMPRS
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Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.
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