Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 1, Issue 2, Pages 480-484Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jz900276x
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- Grants-in-Aid for Scientific Research [22550007] Funding Source: KAKEN
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Ultrafast intersystem crossing of UVA-sensitive 4-thiothymidine in aqueous solution was investigated by pump-probe transient absorption 4-Thiothymidine in the excited singlet state exhibited a distinctively different photophysical pathway from that of thymidine with intersystem crossing to the triplet manifold being dominant and the triplet formation being completed within approximately 10 ps. This was further supported by quantum chemical calculations. We propose that the unique behaviour of photoexcited 4-thiothymidine results from its distinctive molecular and electronic structures and that the triplet form is the initial toxic source to DNA and other biomolecules.
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