Journal
JOURNAL OF PHYSICAL CHEMISTRY C
Volume 116, Issue 17, Pages 9608-9615Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp301316e
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Funding
- UGC (India)
- CSIR (India)
- DST (India) [SR/SO/BB-15/2007]
- National Nanotechnology Center, National Science & Technology Development Agency (NSTDA)
- Ministry of Science and Technology (MOST), Thailand
- Centre of Excellence in Nanotechnology at the Asian Institute of Technology, Thailand
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Bilirubin (BR) is a protective antioxidant; however, when its conjugation and excretion are impaired, as in neonatal and hereditary jaundice, BR accumulates and may cause severe neurotoxicity. Here, we report a novel mechanism for ZnO nanoparticle (NP)-sensitized BR degradation via defect-mediated nonradiative energy transfer pathway. Among different sizes and shapes, ZnO particles with diameter of 5 nm having very high concentration of defect states are found to be the most effective catalyst, which particularly follows a pseudofirst-order kinetics validating the Langmuir-Hinshelwood model of surface catalysis. The nontoxic wide band gap ZnO NPs essentially transmit defect-mediated visible optical radiation, which is not supposed to interfere with the conventional phototherapy process. Therefore, the recyclable ZnO nanocatalysts essentially invite an added advantage in potential therapeutic applications and/or in a flow-device that has been explored in the present study.
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