Journal
JOURNAL OF PHYSICAL CHEMISTRY C
Volume 116, Issue 38, Pages 20558-20563Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp305211d
Keywords
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Funding
- National Natural Science Foundation of China [20175009, 21275015]
- State Key Project of Fundamental Research of China [2011CB932403, 2011CBA00503]
- Program for New Century Excellent Talents in University of China [NCET-10-0213]
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By using water as an exclusive solvent, a facile one-pot strategy was developed for the preparation of hydrophilic magnetite nanofluids coated with oxidized dextran. These as-synthesized magnetic nanofluids are highly water-soluble, biocompatible, and bioconjugatible for targeted detection because of the enriched carboxylate groups in the oxidized dextran shell. These nanoparticles are less than 10 nm and demonstrate strong magnetization, low cytotoxicity, and high T-2-weighted MR image signal intensity (r(2) = 250.5 mM(-1) s(-1) 3.7 times larger than the commercial product). Also, these magnetic nanofluids are highly stable in many kinds of aqueous media; even though a strong magnet is adjoined to the nanofluids, the whole colloid solution rather than the solid particle only is drawn to the side wall of the vial. These novel properties render this magnetic nanofluid desirable for wide bioapplications including MRI, highly efficient magnetic bioseparation, targeted drug delivery, and magnetic hypertherrnia.
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