Journal
JOURNAL OF PHYSICAL CHEMISTRY C
Volume 113, Issue 7, Pages 2676-2684Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp8076672
Keywords
-
Funding
- NCI [CA119397]
- NY Center of Excellence
- U. S. Air Force of Scientific Research
- John R. Oishei Foundation
- AACR-Pancreatic Cancer Action Network Fellowship for Pancreatic Cancer Research
Ask authors/readers for more resources
In this paper, we report the use of bioconjugated gold nanorods and silver nanoparticles as targeted localized surface plasmon resonance enhanced scattering probes for dark-field multiplex and transmission electron microscopy (TEM) imaging of pancreatic cancer cells. We take advantage of the spectrally widely separated localized plasmon resonance of the gold nanorods and silver nanoparticles which produce wavelength selective plasmon resonance scattering to allow multiplex imaging with high contrast. When the surfaces are functionalized, aqueous dispersions of bioconjugated gold nanorods and silver nanoparticles are prepared. We demonstrate receptor-mediated delivery of bioconjugated gold nanorods and silver nanoparticles simultaneously into pancreatic cancer cells, using multiplexed dark-field microscopy technique. We also show that the bioconjugated metallic nanostructures can be used for high-contrast TEM imaging as well.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available