Journal
JOURNAL OF PHYSICAL CHEMISTRY C
Volume 114, Issue 16, Pages 7231-7235Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp905493u
Keywords
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Funding
- EPSRC (U.K.) [EP/D063329/1, EP/E007627/1]
- Generalitat de Catalunya and EU (Beatriu de Pinos)
- Commission of the European Communities
- EPSRC [EP/D063329/1, EP/E007627/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D063329/1, EP/E007627/1] Funding Source: researchfish
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We demonstrate a method that by design reproducibly exploits hot spots in metal nanoparticle aggregates for disease-specific enzyme detection using SERS. Crucially, the reporter molecule is placed within a self-assembled bioactive gold nanostructure, at the optimal EM hot spot position, overcoming the main problem of conventional SERS-active modalities. The scheme exploits the extreme sensitivity of SERS and demonstrates the principle for a method with the potential to be highly competitive with existing immunoassay methods.
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