High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide

A novel graphene oxide-doxorubicin hydrochloride nanohybrid (GO-DXR) was prepared via a simple noncovalent method, and the loading and release behaviors of DXR on GO were investigated. An efficient loading of DXR on GO as high as 2.35 mg/mg was obtained at the initial DXR concentration of 0.47 mg/mL. The loading and release of DXR on GO showed strong pH dependence, which may be due to the hydrogenbonding interaction between GO and DXR. The fluorescent spectrum and electrochemical results indicate that strong pi-pi stacking interaction exists between them.