Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 115, Issue 16, Pages 4880-4886Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp2022727
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Funding
- CICYT [MAT2009-12364]
- CSIC (Consejo Superior de Investigaciones Cientificas, Spain) [PIE-2008501072]
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An exhaustive umbrella sampling simulation of the alanine dipeptide in solution is reported The presence of stable Y conformations in solution is assessed by both quantum calculations and experimental data from X-ray and NMR protein-solved structures available in the protein coil library. The agreement between experimental and simulation Ramachandran plots of the dipeptide in solution is excellent. A suitable explanation of the stabilization of the Y conformation mediated by water for the alanine dipeptide is discussed on the basis of Car-Parrinello MD calculations of the dipeptide in water.
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