4.5 Article

Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Enzyme Inhibition by a Substrate

Journal

JOURNAL OF PHYSICAL CHEMISTRY B
Volume 115, Issue 32, Pages 9838-9845

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jp2041372

Keywords

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Funding

  1. NSF [CCF-1015983]
  2. Direct For Computer & Info Scie & Enginr
  3. Division of Computing and Communication Foundations [1015983] Funding Source: National Science Foundation

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We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme which can be inhibited by a substrate when the latter is inputted at large enough concentrations. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate. The obtained data are fitted for gate quality evaluation within the developed model, and we discuss aspects of devising XOR gates for functioning in biocomputing systems utilizing biomolecules for information processing.

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