Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 114, Issue 2, Pages 1213-1220Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp910953w
Keywords
-
Categories
Funding
- Czech Science Foundation [203/08/0114]
- Czech Ministry of Education [LC512]
- National Science Foundation [CHE-0431312, CHE-0209719]
- International Max-Planck Research School
- Institute of Organic Chemistry and Biochemistry [Z4 055 0506]
- Deutsche Forschungsgemeinschaft (DFG)
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [909227] Funding Source: National Science Foundation
Ask authors/readers for more resources
Affinities of alkali cations and halide anions for the peptide group were quantified using molecular dynamics simulations of aqueous solutions of N-methylacetamide using both nonpolarizable and polarizable force fields, Potassium and, more strongly, sodium exhibit an affinity for the carbonyl oxygen of the amide group, while none of the halide anions shows any appreciable attraction for the amide hydrogen. Heavier halides, however, interact with the hydrophobic methyl groups of N-methylacetamide. Using the present results for a model of the peptide bond we predict that the destabilizing effect of weakly hydrated Hofmeister ions, Such as bromide or iodide, is not due to direct interactions with the backbone but rather due to attraction to hydrophobic regions of the protein.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available