Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 113, Issue 5, Pages 1468-1472Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp8046032
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Funding
- National Natural Science Foundation of China [60701009, 10704015]
- Cultivation Fund
- Ministry of Education of China [70401 F]
- Science and Technology Development Foundation of Jilin Province
- Ministry of Education [20070200010]
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A new method of protein detection was explored on the resonant Raman scattering signal of ZnO nanoparticles. A probe for the target protein was constructed by binding the ZnO/Au nanoparticles to secondary protein by eletrostatic interaction. The detection of proteins was achieved by an antibody-based sandwich assay. A first antibody, which could be specifically recognized by target protein, was attached to a solid silicon surface. The ZnO/Au protein probe could specifically recognize and bind to the complex of the target protein and first antibody. This method on the resonant Raman scattering signal of ZnO nanoparticles showed good selectivity and sensitivity for the target protein.
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