Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 113, Issue 35, Pages 11787-11792Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp904251j
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Funding
- CSIR, New Delhi, India
- Nanoscience and Technology Initiatives, DST, Government of India, New Delhi
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Here, we report two synthetic oligopeptide-based, thermoreversible, pH-sensitive hydrogels. In gel phase, these self-assembling tetrapeptides form a long interconnected nanofibrilar network structure, as is evident from various microscopic techniques, including field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM). FTIR, circular dichroism, and wide angle X-ray diffraction (WAXD) favor an antiparallel beta-sheet structure of these gelators in the gel state. Finally, these hydrogels have been utilized for entrapment and slow release of an anticancer drug doxorubicin at physiological pH, promising their future application as a drug delivery vehicle.
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