Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 113, Issue 49, Pages 16065-16070Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp9079052
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Funding
- National Science Foundation [CCF-0726698, DMR-0706209]
- Office of Naval Research [N00014-08-1-1202]
- Semiconductor Research Corporation [2008-RJ-1839G]
- Clarkson University
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The logic gates NAND/NOR were mimicked by enzyme biocatalyzed reactions activated by sucrose, maltose and phosphate. The subunits performing AND/OR Boolean logic operations were designed using maltose phosphorylase and cooperative work of invertase/amyloglucosidase, respectively. Glucose produced as the output signal froth the AND/OR subunits was applied as the input signal for the INVERTER gate composed of alcohol dehydrogenase, glucose oxidase, microperoxidase-11, ethanol and NAD(+), which generated the final output in the form of NADH inverting the logic signal from 0 to 1 or from 1 to 0. The final output signal was amplified by a self-promoting biocatalytic system. In order to fulfill the Boolean properties of associativity and commutativity in logic networks, the final NADH output signal was converted to the initial signals of maltose and phosphate, thus allowing assembling of the same standard units in concatenated sequences. The designed modular approach, signal amplification and conversion processes open the way toward complex logic networks composed of standard elements resembling electronic integrated circuitries.
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